Mesothelioma Stages

Mesothelioma Stages


How is mesothelioma staged?

Staging is the process of finding out how far the cancer has spread. Staging of mesothelioma is based on imaging studies such as x-rays, CT scans, and MRI scans. The mesothelioma treatment and life expectancy for patients with the disease largely depends on the stage (extent of spread) of their cancer. Since pleural mesothelioma occurs most frequently and has been studied the most, it is the only mesothelioma for which a staging classification exists.
Mesothelioma Staging Systems

Today, there are three primary staging systems used to assess how far mesothelioma cancer has spread and each system uses four stages to describe the progression of the disease. It is the definition of each stage within the various systems that can vary slightly.
Butchart Staging System

The staging system most often used for mesothelioma cancer is the Butchart system and is focused on defining the location of the primary tumor mass in body for each stage. The system doesn’t address how many cancer cells are present, how big the tumor is or the level of cancer present in the body overall.
TNM Staging System

The TNM Staging System, developed by the American Joint Committee on Cancer (AJCC), is similar to staging systems used for other types of cancer. It considers the characteristics of the tumor (T), whether or not lymph nodes are involved (N) and if the cancer has metastasized to other locations in the body (M).
Brigham Staging System

The Brigham Staging System also has four stages of progression and is very similar to the TNM Staging System. The primary difference between the two is that in addition to defining the location of the tumor, and assessing lymph node involvement and the presence of metastatic disease, the Brigham System also helps assess the possibility for and effectiveness of surgical intervention at each stage.
The Stages of Mesothelioma

The four stages of mesothelioma, as noted above, vary slightly within each system but can be generally characterized as indicated below. Please click into the individual pages to get more information about each stage in general and as is it defined within each staging system:
Stage 1 Mesothelioma

In Stage 1 the tumor is localized, there is no lymph node involvement and the cancer has not spread to other organs or tissues.
Stage 2 Mesothelioma

In Stage 2, the tumor is larger and has invaded the lung or diaphragm. Lymph nodes may also be involved.
Stage 3 Mesothelioma

In Stage 3, mesothelioma has invaded a single region or area such as the chest wall.
Stage 4 Mesothelioma

In Stage 4, mesothelioma has invaded multiple regions such as different areas of the chest wall, the diaphragm and/or the pericaridium. Lymph glands are also involved and the cancer has spread to other organs.
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